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Articles |
By David Edelman
Published: February 16, 2008
Updated: September 3, 2008
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Interview: Type 1 Diabetes Cure Trial from David Edelman on Vimeo.
If you or a loved one has type 1 diabetes, this interview with Dr. Denise Faustman is a must-watch. Dr. Faustman's lab was the first in the world to cure naturally diabetic mice. A clinical trial is underway to test this cure in human beings.
BACKGROUND In 2003, after over a decade of work, Dr. Faustman became the first person to cure diabetes in naturally diabetic mice. This was not a treatment, like injecting islet cells or transplanting a pancreas. Dr. Faustman's mice had a genetic disorder that caused them to develop diabetes naturally. Once her mice reached old age (about a year in mice time), she treated them with a two-drug combination to kill the defective t-cells that were destroying their insulin producing function. The stunning result: the mice regrew their beta cells and began naturally producing insulin again! This experiment has been repeated and verified independently by a half dozen labs since.
In the past, there have been many false alarms on the "mouse cure" front. Treatments have been sold as cures or a reported cure was unable to be repeated. This is the real deal. The mice had diabetes into their old age, and this treatment cured them. Other labs have verified the results.
Dr. Faustman is now in the middle of a stage 1 clinical trial to test this technique in humans. Using special blood-testing equipment that's taken years and millions of dollars to develop, her team is measuring whether the BCG vaccine is able to measurably reduce the number of defective t-cells.
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